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About This Item
Full Description
1.3 During the performance of the Human Repeat Insult Patch Test (RIPT) for determining sensitization, investigators are confronted with skin responses that represent skin irritation (non-immunologic responses) or allergic contact dermatitis (ACD). The numerical scoring system for grading the intensity of both are similar and test facilities may vary in their scores that describe intensities of allergic and irritant skin responses. The hallmark of a mild allergic contact dermatitis is a sustained palpable erythematous reaction. Delayed-type allergic contact reactions from patch tests have intensity characteristics that favor scores of higher values for longer periods of time and typically do not produce a minimal score (score of 1, a just-perceptible erythema) for short durations (less than 48 h). It is the responsibility of the investigator to evaluate the scores in light of irritant reactions so that the responses are allergic in nature and not irritant. The investigator should denote a final score as either due to contact allergy or irritation. Paragraphs 9.5-9.5.5 describe a commonly used scoring system and discuss allergic and irritant responses in detail.
Document History
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ASTM D6355-07(2022)
Standard Test Method for Human Repeat Insult Patch Testing of Medical Gloves- Most Recent
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ASTM D6355-07(2017)
Standard Test Method for Human Repeat Insult Patch Testing of Medical Gloves- Historical Version
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ASTM D6355-07(2012)
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Standard Test Method for Human Repeat Insult Patch Testing of Medical Gloves- Historical Version
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ASTM D6355-07
Standard Test Method for Human Repeat Insult Patch Testing of Medical Gloves- Historical Version
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ASTM D6355-98(2003)
Standard Test Method for Human Repeat Insult Patch Testing of Medical Gloves- Historical Version
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ASTM D6355-98
Standard Test Method for Human Repeat Insult Patch Testing of Medical Gloves- Historical Version