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This paper considers the heat transfer and pressure drop performance potentials of halogentated propene isomers during in-tube condensation and in-tube flow boiling using the penalty factor and total temperature penalization concepts, respectively. In particular, five isomers are considered: R-1233xf, R-1233zd(E), R-1234yf, R-1234ze(E), and R-1243zf. In addition, to these five pure fluids, the heat transfer and pressure drop performance potentials of five R-32/R-1234yf blends are considered. The paper also presents thermophysical property estimations for the five pure fluids relative to R-134a, R-245fa, and R-123. The thermophysical properties considered are the ones that influence the heat transfer and pressure drop performance potentials, and include the thermodynamic properties temperature, pressure, density, latent heat of vaporization, and specific heat, and the transport properties thermal conductivity and viscosity. The paper also presents a literature review of relevant articles for condensation and boiling heat transfer and pressure drop of fluorinated propene isomers.