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The HVAC requirements for facilities using radioactive materials are discussed in this chapter. Such facilities include nuclear power plants, fuel fabrication and processing plants, plutonium processing plants, hospitals, corporate and academic research facilities, and other facilities housing nuclear operations or materials. The information presented here should serve as a guide; however, careful and individual analysis of each facility is required for proper application. GENERAL DESIGN ISSUES As Low as Reasonably Achievable (ALARA) Design Normal or Power Design Basis Safety Design Basis Outdoor Conditions Indoor Conditions Indoor Pressures Airborne Radioactivity Tornado/Missile Protection Fire Protection Smoke Management DEPARTMENT OF ENERGY FACILITIES Confinement Systems Ventilation COMMERCIAL FACILITIES Operating Nuclear Power Plants New Nuclear Power Plants PLANT HVAC&R SYSTEMS Pressurized-Water Reactors Boiling-Water Reactors Heavy Water Reactors Areas Outside Primary Containment Nonpower Medical and Research Reactors Laboratories Decommissioning Nuclear Facilities Waste-Handling Facilities Reprocessing Plants Mixed-Oxide Fuel Fabrication Facilities