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In this study, Cryptosporidium parvum was exposed to ultraviolet (UV) andgamma radiation. Inactivation responses were measured using the Foci Detection Method (FDM) and were enumerated using the Most Probable Number (MPN) procedure. Previous studies suggested that UV doses on the order of hundreds to thousands mW-s/cm2 were required to inactivate Cyryptosporidium. Resultsfrom this study indicated that Cryptosporidium was inactivated by both disinfectants over several orders of magnitude at doses comparable to those required for inactivation of bacteria and viruses. Based on these results, UV and gamma radiation appear to be effective physical disinfectants for the inactivation of Cryptosporidium parvum. Includes 26 references, tables.