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Prior investigations have identified many of the mechanisms by which natural organic matter (NOM), coagulant, and particles interact in ozonated systems. This study investigated the effects of ozonation on coagulation with cationic polymer and with polymer-metal salt mixtures. Preozonation decreased the concentration of NOM that reacts with polymer, reducing organic carbon removal, polymer coagulant demand, and the rate of head loss buildup during direct filtration. The effects of ozonation in systems using dual coagulants (alum-polymer or ferric chloride-polymer) were a blend of the effects observed for the coagulants individually. Includes 20 references, tables, figures.