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Because it is not practical to analyze for each individual chemical compound present in natural organic matter (NOM), surrogate characterization methods were sought that could identify interrelationships between NOM and its treatability. Source-related and seasonal differences, effects of ozonation and coagulation on NOM, characterization of NOM in sequential unit processes including granular activated carbon, and aspects of bromide-NOM interactions are explored. Whereas coagulants remove NOM intact, particularly higher-molecular-weight fractions, ozone converts humic to nonhumic material, resulting in NOM fractions that could be difficult to remove by subsequent coagulation. Bromide ion can confound analytical interpretation of separation techniques unless the bromide concentration is equalized in the individual fractions. Includes 30 references, tables, figures.