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This article examines the effect of common water quality variables on disinfection by-products (DBP) formation to better balance free chlorine disinfection with disinfection DBP formation. The water quality variables evaluated are pH, temperature, chlorine dosage, and total organic carbon (TOC) concentration. This article examines how these variables affect the concentrations of trihalomethanes (THMs) and haloacetic acids (HAAs) at the shorter contact times associated with the use of chloramines, rather than chlorine, for residual disinfection. Five case studies evaluated DBPs in five water sources of differing quality. The information here is intended to assist others in quantifying the effect of water quality on DBP formation and to design and operate free chlorine and monochloramine disinfection systems. Includes 22 references, tables, figures.