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This research evaluates the chemical and bacteriological water quality deterioration from treatment plant finished water to the point of consumption in the Bangkok, Thailand, water distribution system, and focused on the role of water transmission mains and extension distribution systems (premise plumbing) on water quality deteriorations. Samples were collected with an extensively spatial and temporal pattern to examine the water quality deteriorations (physical, chemical and microbiological water quality changes) in the Bangkok metropolitan area. Locations were included with various premise types (school, residential, hospital, business), premise plumbing design (storage, wet fire system, and filtered or unfiltered) and water use patterns (high/low demand, day/night demand). Statistical analysis was conducted to find if significant predictors exist for water quality deteriorations within these systems. The effectiveness of engineering interventions would be evaluated upon successful identification of contamination/regrowth sources.