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Ozone can be used for a variety of purposes in the treatment of drinking water. This article provides an overview of three interrelated ozone applications--disinfection by-product control, organics removal, and disinfection--along with the key issues affecting each. Disinfection byproduct control can be effected through precursor removal, optimized coagulation, or destruction of precursors. Organics removal encompasses taste and odor, color, and volatile organic chemicals. In addition to summarizing the literature, the article describes the results of bench- and pilot-scale studies performed by the Metropolitan Water District of Southern California. Research needs are identified. Some guidelines for implementing ozonation are given. PEROXONE is also discussed. Includes 50 references.