This article provides an overview on the use of hydrocarbon refrigerants in commercial refrigeration and air conditioner appliances. The general motivation for the shift towards so-called "natural" refrigerants and in particular, hydrocarbons, is discussed. Different refrigerant options for use in such appliances are summarised and compared against the leading hydrocarbon options: R290 (propane), R1270 (propene) and R600a (iso-butane). A review of various studies associated with the performance of these refrigerants in commercial refrigeration and air conditioning systems is provided alongside theoretical calculations. Given the concern over the flammability of hydrocarbons, safety matters are addressed in detail, covering flammability characteristics, safety standards, charge size reduction and other features which assist with improving safety and flammability risk analysis. More commercial aspects related to costs associated with implementing hydrocarbons and the current status of their use is also mentioned