The paper discusses the applications of CO₂-based demand-controlled ventilation DCV strategy integrated with theeconomizer for air source heat pumps in schools, investigates their impact on the annual energy consumption, anddetermines the potential savings achieved in different USA locations. The study includes detailed energy analysis on anexisting middle school through whole building simulation energy software. The simulation model is first calibrated andchecked for accuracy using actual monthly utility data. This model is then used for savings calculations resulted from acombination of air-side economizer and CO₂-Based DCV and with various occupancy profiles and locations. The resultsshow that a significant saving could be obtained as compared to the actual operating strategy implemented in the existingsystem and this saving depends mainly on the actual occupancy profile and building locations.