The biocidal potential of total residual chlorine (TRC), monochloramine, monochloramine plus excess ammonia, ammonia, bromine, and copper for controlling the Asiatic clam (Corbicula fluminea) was investigated. Monochloramine with excess ammonia was found to be most effective for controlling Corbicula at 30C. Although copper appeared to be the most toxic biocide, plant studies indicated that laboratory tests had overestimated clam sensitivity. Chlorination at 0.25-0.40 mg TRC/L at 20-25C controlled clams of all sizes in two to four weeks but had minimal effect at 12-15C. The toxicity of all thebiocides was highly dependent on temperature and clam size. Includes 38 references, tables.