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The use of mixed gas working fluids has become common in Joule–Thomson typecryocoolers for a variety of applications. However, there is a scarcity of data currently availablewith supporting theory capable of predicting the heat transfer coefficients associated with twophase,multi-component mixtures at cryogenic temperatures. This document describes anexperimental facility designed and constructed to measure the heat transfer coefficients andfrictional pressure drop in small diameter, horizontal test sections with two-phase, multicomponentzeotropic mixtures at cryogenic temperatures. The aim of this facility is to enable thecollection of high accuracy data to overcome the scarcity of heat transfer and pressure drop datafor zeotropic mixtures undergoing a phase change (boiling). Results are available forhydrocarbon mixtures (comprised of methane, ethane, and propane) and synthetic refrigerantmixtures (including R14, R23, R32, and R134a), which are commonly used in small Joule–Thomson cryocoolers. The measured heat transfer coefficients for hydrocarbon and syntheticmixtures included nitrogen and argon, respectively for dilution.